Researchers can also culture tumor cells and conduct tumor invasion assays with tumor spheroids to visualize the invasion of cancer cells and also screen inhibitors. These 3D culture models can create systems to mimic healthy cells or diseased cells and by using these systems, researchers can evaluate cellular responses to different drug candidates early in development. 3D culture is particularly important here as there is significant evidence that 3D models frequently respond differently to compounds than 2D models. One area where 3D culture models can be very useful is in cancer research where 3D culture models can be used to predict and model drug responses for drug compound screening and toxicity testing. Applications for 3D Culture – Cancer Research Spheroids form spontaneously and some examples of multi-cellular spheroids include embryoid bodies, mammospheres, tumor spheroids, hepatospheres and neurospheres. They can be generated from a wide range of cell types and methods. The most common 3D culture models are spheroids (3D cell aggregates). This is particularly important in research where in vivo biological relevance is critical. In many applications, 3D cell culture models have been established as a more accurate research model than 2D cultures. Enabling High Throughput 3D Cell Culture Using Automation
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